The pharmacokinetics of theophylline (aminophylline 5.8 mg/kg infused over 20 minutes) were unmodified adhering to a single oral dose of albendazole (400 milligrams) in 6 healthy and balanced subjects.
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Lasting carcinogenicity researches were conducted in mice and rats. In the computer mouse research, albendazole was administered in the diet at dosages of 25, 100, and also 400 mg/kg/day (0.1, 0.5, and also 2 times the advised human dose based on physical body surface location in mg/m2, specifically) for 108 weeks. In the rat research study, albendazole was administered in the diet plan at doses of 3.5, 7, and 20 mg/kg/day (0.04, 0.08, and 0.21 times the recommended human dose based on body surface area in mg/m2, respectively) for 117 weeks. There was no evidence of increased incidence of growths in the treated mice and also rats when as compared to the command team.
In genotoxicity driving tests, albendazole was located negative in an Ames Salmonella/Microsome Plate alteration assay with and also without metabolic activation or with as well as without pre-incubation, cell-mediated Chinese Hamster Ovary chromosomal aberration test and in vivo mouse micronucleus examination. In the in vitro BALB/3T3 cells improvement assay, albendazole produced weak activity in the existence of metabolic activation while no activity was located in the lack of metabolic activation.
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